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Juha E Jääskeläinen

Curriculum vitae

Previous and present positions:
University of Eastern Finland and Kuopio University Hospital:
Full Professor of Neurosurgery / Institute of Clinical Medicine / Faculty of Health Sciences / UEF University of Eastern Finland / Kuopio / Finland, 2004–
Chairman of Neurosurgery / KUH NeuroCenter / KUH Kuopio University Hospital / Kuopio / Finland, 2004–
Director of Kuopio Intracranial Aneurysm Database www.uef.fi/ns, 2004–
Director of KUH Neuro-oncology Group (service with Cyber Knife 2012–), 2005–
Neurosurgery of Helsinki University Hospital:
Resident / Staff Neurosurgeon / Lecturer / Head of Department, 1978–2004
Director of Neuro-oncology Program, 2000–2004
Director of Intracranial Aneurysm Experimental Research Group at Helsinki Biomedicum, 2000–2004

Education and Degrees:
MD – Medical School / Kuopio University / Kuopio / Finland, 1977
Neurosurgeon – Neurosurgery / HU Helsinki University / Helsinki / Finland, 1985
PhD (4 international peer-reviewed articles) – HU Neurosurgery with Prof Matti Haltia / HU Neuropathology and Prof Timo Hakulinen / Finnish Cancer Registry, 1986
Senior Research Fellow (27 mos) – HU Pathology with Docent Tuomo Timonen, 1987–1992 Docent of Neurosurgery (20 international peer-reviewed articles) / HU, 1995
Visiting Professor (11 mos) – Neurosurgery with Prof Peter McL Black / Brigham and Women’s Hospital / Harvard Medical School / Boston MA, 2001–2002
Second Lieutenant – Medical Reserve Officer School / Finnish Defense Forces, 1979

Personal Competed External Research Funding (received):
1.621 million euros personal competed external research funding received by 22 August 2015

Clinical and Translational Research on Saccular Intracranial aneurysm (sIA) Disease 2000-
2000-2004
Director of Intracranial Aneurysm Experimental Research Group at Helsinki Biomedicum Creation of sIA Family Registry of Helsinki Neurosurgery
Creation of Helsinki Neurosurgery Human sIA Tissue Bank (n >700) Creation of microvascular laboratory and experimental rodent aneurysm model
2004-
Director of Kuopio Intracranial Aneurysm Database and Family Registry www.uef.fi/ns

Previous Research 1982–2000 – Molecular Biology and Longterm Outcome of Inherited Central Nervous System Tumor Traits at HU Pathology and Finnish Cancer Registry:
Post Doc and Senior Researcher 1986 – 1992 / HU Pathology and Finnish Cancer Registry
Co-PI of Ezrin-Merlin Study Group 1992 – 00 / HU Pathology and Virology 
PI of Feasibility of Boron Neutron Capture Therapy (BNCT) in Neurofibromatosis 2

Co-Organizer of Infrastructure for Population-Based Neurocare at KUH NeuroCenter:
KUH NeuroCenter (Neurosurgery + Neurology + Kuopio Epilepsy Center) 2010-
KUH NeuroGroups – Neuro-oncology + CyberKnife / Neurovascular / Epilepsy / Normal Pressure Hydrocephalus / Spine / Neuromodulation / Brain Mapping and Intraoperative Monitoring / etc
KUH Neurodisease Databases for Eastern Finnish catchment population – Intracranial Aneurysms / Normal Pressure Hydrocephalus / Degenerative Cervical Spine Surgery / Spinal Cord Stimulation

Introduction of New Methods and Technologies for Neuro-oncology in Finland:
Preoperative functional brain mapping (fMRI MEG nTMS) and data integration into navigated operation microscope – awake craniotomies – intraoperative electric cortical and white matter stimulation mapping – brachytherapy with stereotactic isotope implantation – stereotactic radiotherapy with linear accelerator and CyberKnife – multidisciplinary Neuro-Oncology Group

Clinical Advisor and Co-Developer of Medical Technologies for Clinical Neurocare:
MEG brain mapping for neurosurgery – Clinical Advisor to NeuroMag (Elekta Neuromag) (ended)

Navigated Transcranial Magnetic Stimulation (nTMS) mapping for neurosurgery and radiosurgery:
* Clinical Advisor of NexStim (www.nexstim.com) / Henri Hannula Vice President Sales Europe
* with KUH Neurophysiology Brain Mapping and Intraoperative Monitoring / Prof Esa Mervaala / awake craniotomies with intraoperative cortical and white matter stimulation mapping
* 1st installation of NexStim device 2006 – mapping of motor and speech cortical areas / transfer of data into navigated operation microscope and CyberKnife dose planning
* PI of KUH Partner (NeuroCenter + Neurophysiology) in PAMSCAN (multifocal nTMS device) / PI Academy Professor Risto Ilmoniemi / Horizon 2020 Health (pending)

Creation of novel EEG electrodes with UEF Applied Physics and KUH Neurophysiology:
* High-density cortical grids for EEG analysis in rodents
* Disposable scalp electrodes for acute neurocare (vendor Mega Electronics / Kuopio Finland)

Development of advanced intraoperative photonics for neurosurgical microscopes and endoscopes:
* Creation of spectral analysis work station for operative microscope and endoscope with Prof Markku Hautakasari PhD / UEF Institute of Photonics (www.uef.fi/spectral)
* Creation of gaze tracking and gaze command systems for neurosurgical microscope with Docent Roman Bednarik PhD / UEF Interactive Technologies (www.cs.joensuu.fi)

Positions of Trust in Finnish Health Care:
Ministry of Social Affairs and Health of Finland:
Member of Organizing Committee for Comprehensive Cancer Center Finland 2012-2013
Member of Organ Donation Committee 2013-
Neurosurgical Expert in Patient Complaint / Malpractice cases:
National Supervisory Authority for Welfare and Health (VALVIRA) 2009-
National Patient’s Injuries Board 2012-

Scientific and Academic Reviewer and Member of Boards:
EANS Acta Neurochirurgica / Editorial Board – 450 neuro-oncology manuscript reviews 2009-
EANS Research Committee – Young Neurosurgeon’s Reseach Prize reviewer
Member of 10 Professorship Evaluation Committees – 7 at UEF / 3 international
Cancer Society of Finland – about 1500 grant application reviews
- Member / Grant Evaluation Committee for Basic Cancer Research 2009-2011
- Chairman / Grant Evaluation for Clinical Cancer Research 2012-2015
Vaajasalo Epilepsy Research Foundation – Member of Assembly of Delegates 2013-
Petri Honkanen Research Foundation – Member of Board 2014-

Annual Lecturer and Board Member in International Research and Clinical Courses:
EANS European Association of Neurosurgical Societies (www.eans.org)
- Member of EANS Research Committee (Research Courses / Aesculap Prizes) 2003-
- Lecturer in EANS Training Courses for Neurosurgery Residents
Scandinavian Neurosurgery Resident Training Week – Member of Organizing Committee 2003-
Helsinki Annual Live Course Week in Microneurosurgery – Teacher and Faculty Member 2001-
UEF Clinical Research School (www.uef.fi/dpcr) – Member of Board 2010-

Awards:
Ludvig Puusepp Honorary Lecture / University of Tartu / Estonia 2014

Publications / Scholarship / Mentoring:
H-index 41 (ISI Web of Science) – 18 publications with >100 citations
156 original articles in peer-reviewed international medical journals

11 Neurosurgeons trained (6 yrs program) – M Fraunberg / J Frösen / J Huttunen / T Huttunen /
- P Karamanakos / S Koponen / O Kämäräinen / V Leinonen / A Lindgren / P Sandell / V Soppi
10 supervized PhD Theses
- HU – A Mäenpää 1997 / M Seppälä 1998 / J Antinheimo 1999 / M Sainio 2000 / M Niemelä 2000 / J Frösen 2006
- UEF – T Huttunen 2012 / A Lindgren 2013 / M Kurki 2013 / K Coco 2014
10 on-going PhD supervisions
- UEF – J Björkman / J Halonen / J Huttunen / J Kolivuori / M Meklin / M Nissen / S Räisänen / H Tattari / I Tiihonen; HU – H Andrade
25 other PhD Theses supported as co-author of Thesis articles

Promoted Post Doc periods at highest ranking universities – Harvard (Niemelä 2001-2 / Antinheimo 2001-2 / Frösen 2009 / Kurki 2014 -) – Cambridge UK (T Huttunen 2013) – Macquarie Australia (T Koivisto 2006-7)
Mentored until Docentship – Fraunberg / Frösen / Koivisto / Leinonen / Niemelä / Savolainen
Future Professorships in Neurosurgery – Fraunberg / Frösen / Leinonen / Niemelä / Fraunberg / Leinonen / Niemelä applied HU Professorship in Neurosurgery in May 2015
UEF Professorship in Clinical Epileptology – Reetta Kälviäinen granted by Vaajasalo Foundation

10 publications of my PhD Students – now Researchers in my Kuopio sIA Group:
Jukka Huttunen is my PhD Student (on-going) and Trainee in Neurosurgery (completed)
* Huttunen J et al. Epilepsy after aneurysmal subarachnoid haemorrhage – a population based long-term follow up study. Neurology 2015 epub IF=8.3
Antti Lindren is my PhD Student (completed) and Trainee in Neurosurgery (ongoing)
* Lindgren AE et al. Hypertension predisposes to the formation of saccular intracranial aneurysms in 467 unruptured and 1053 ruptured patients in Eastern Finland. Ann Med 46:169-76, 2014 IF=4.7
* Lindgren AE, et al. Type 2 diabetes and risk of rupture of saccular intracranial aneurysm in Eastern Finland. Diabetes Care 36:2020-6, 2013 IF=8.6
Mitja Kurki is my PhD Student (completed) and Post Doc (2014 -) at Broad Institute, Boston
* Kurki MI et al. High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms. PLoS Genet 2014 IF=8.2
* Kurki MI et al. Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-κB, hypoxia-inducible factor-1A, and ETS transcription factors. Neurosurgery 68:1667-75, 2011 IF=3.0
Petros Karamanakos is my Trainee in Neurosurgery (completed)
* Karamanakos PN et al. Risk Factors for Three Phases of 12-Month Mortality in 1657 Patients from a Defined Population After Acute Aneurysmal Subarachnoid Hemorrhage. World Neurosurg 78:631-9, 2012 IF=2.4
Terhi Huttunen is my PhD Student (completed) and Trainee in Neurosurgery (on-going)
* Huttunen T et al. Long-term excess mortality of 244 familial and 1502 sporadic one-year survivors of aneurysmal subarachnoid hemorrhage compared with a matched Eastern Finnish catchment population. Neurosurgery 68:20-7, 2011 IF=3.0
* Huttunen T et al. Saccular intracranial aneurysm disease: distribution of site, size, and age suggests different etiologies for aneurysm formation and rupture in 316 familial and 1454 sporadic Eastern Finnish patients. Neurosurgery 66:631-8, 2010 IF=3.0
Docent Juhana Frösen is my PhD Student (completed) and Trainee in Neurosurgery (completed)
* Frösen J et al. Contribution of mural and bone marrow-derived neointimal cells to thrombus organization and wall remodeling in a microsurgical murine saccular aneurysm model. Neurosurgery 2006;58:936-44 IF=3.0 Cited 25
* Frösen J et al. Growth factor receptor expression and remodeling of saccular cerebral artery aneurysm walls: implications for biological therapy preventing rupture. Neurosurgery 2006;58:534-41 IF=3.0 Cited 49